Ebselen has lithium-like effects on central 5-HT_2A receptor function.

ABSTRACT:

Background and purpose

Lithium's antidepressant action may be mediated by inhibition of inositol monophosphatase (IMPase), a key enzyme in G_q -protein coupled receptor signalling. Recently, the antioxidant agent ebselen was identified as an IMPase inhibitor. Here, we investigated both ebselen and lithium in models of the 5-HT_2A receptor, a G_q -protein coupled receptor involved in lithium's actions.

Experimental approach

5-HT_2A receptor function was assessed in mice by measuring the behavioural (head-twitches, ear scratches) and molecular (cortical immediate early gene [IEG] mRNA; Arc, c-fos, Egr2) responses to 5-HT_2A receptor agonists. Ebselen and lithium were administered either acutely or repeatedly prior to assessment

SUBMITTER: Antoniadou I 

PROVIDER: S-EPMC6003638 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature