Late sodium current inhibitors to treat exercise-induced obstruction in hypertrophic cardiomyopathy: an in vitro study in human myocardium.

ABSTRACT:

Background and purpose

In 30-40% of hypertrophic cardiomyopathy (HCM) patients, symptomatic left ventricular (LV) outflow gradients develop only during exercise due to catecholamine-induced LV hypercontractility (inducible obstruction). Negative inotropic pharmacological options are limited to β-blockers or disopyramide, with low efficacy and tolerability. We assessed the potential of late sodium current (I_NaL )-inhibitors to treat inducible obstruction in HCM.

Experimental approach

The electrophysiological and mechanical responses to β-adrenoceptor stimulation were studied in human myocardium from HCM and control patients. Effects of I_NaL -inhibitors (ranolazine and GS-967) in HCM samples were investigated under conditions simulating rest and exercise.

SUBMITTER: Ferrantini C 

PROVIDER: S-EPMC6003658 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature