Preliminary observations in systemic oxygen consumption during targeted temperature management after cardiac arrest.

ABSTRACT:

Aim

Limited data suggests low oxygen consumption (VO₂), driven by mitochondrial injury, is associated with mortality after cardiac arrest. Due to the challenges of measurement in the critically ill, post-arrest metabolism remains poorly characterized. We monitored VO₂, carbon dioxide production (VCO₂) and the respiratory quotient (RQ) in post-arrest patients and explored associations with outcome.

Methods

Using a gas exchange monitor, we measured continuous VO₂ and VCO₂ in post- arrest patients treated with targeted temperature management. We used area under the curve and medians over time to evaluate the association between VO₂, VCO₂, RQ and the VO₂:lactate ratio with survival.

Result

SUBMITTER: Uber A 

PROVIDER: S-EPMC6003666 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature