How epigenome drives chromatin folding and dynamics, insights from efficient coarse-grained models of chromosomes.

ABSTRACT: The 3D organization of chromosomes is crucial for regulating gene expression and cell function. Many experimental and polymer modeling efforts are dedicated to deciphering the mechanistic principles behind chromosome folding. Chromosomes are long and densely packed-topologically constrained-polymers. The main challenges are therefore to develop adequate models and simulation methods to investigate properly the multi spatio-temporal scales of such macromolecules. Here, we proposed a generic strategy to develop efficient coarse-grained models for self-avoiding polymers on a lattice. Accounting accurately for the polymer entanglement length and the volumic density, we show that our simulation scheme not only captures the steady-state structural and dynamical properties of the system but also

SUBMITTER: Ghosh SK 

PROVIDER: S-EPMC6003694 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature