Acute inhalation of combustion smoke triggers neuroinflammation and persistent anxiety-like behavior in the mouse.

ABSTRACT: CONTEXT:Acute inhalation of combustion smoke triggers neurologic sequelae in survivors. Due to the challenges posed by heterogeneity of smoke exposures in humans, mechanistic links between acute smoke inhalation and neuropathologic sequelae have not been systematically investigated. METHODS:Here, using mouse model of acute inhalation of combustion smoke, we studied longitudinal neurobehavioral manifestations of smoke exposures and molecular/cellular changes in the mouse brain. RESULTS:Immunohistochemical analyses at eight months post-smoke, revealed hippocampal astrogliosis and microgliosis accompanied by reduced myelination. Elevated expression of proinflammatory cytokines was also detected. Longitudinal testing in different neurobehavioral paradigms in the course of post-smoke recovery,

SUBMITTER: Gorgun MF 

PROVIDER: S-EPMC6003701 | biostudies-literature | 2017 Oct - Dec

REPOSITORIES: biostudies-literature