Recent stimulant use and leukocyte gene expression in methamphetamine users with treated HIV infection.

ABSTRACT: Stimulant use may accelerate HIV disease progression through biological and behavioral pathways. However, scant research with treated HIV-positive persons has examined stimulant-associated alterations in pathophysiologic processes relevant to HIV pathogenesis. In a sample of 55 HIV-positive, methamphetamine-using sexual minority men with a viral load less than 200 copies/mL, we conducted RNA sequencing to examine patterns of leukocyte gene expression in participants who had a urine sample that was reactive for stimulants (n = 27) as compared to those who tested non-reactive (n = 28). Results indicated differential expression of 32 genes and perturbation of 168 pathways in recent stimulant users. We observed statistically significant differential expression of single genes previously associ

SUBMITTER: Carrico AW 

PROVIDER: S-EPMC6003871 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature