PET imaging of ⁶⁸Ga-NODAGA-RGD, as compared with ¹⁸F-fluorodeoxyglucose, in experimental rodent models of engrafted glioblastoma.

ABSTRACT:

Background

Tracers triggering αvβ3 integrins, such as certain RGD-containing peptides, were found promising in previous pilot studies characterizing high-grade gliomas. However, only limited comparisons have been performed with current PET tracers. This study aimed at comparing the biodistribution of ¹⁸F-fluorodeoxyglucose (¹⁸F-FDG) with that of ⁶⁸Ga-NODAGA-RGD, an easily synthesized monomeric RGD compound with rapid kinetics, in two different rodent models of engrafted human glioblastoma.

Methods

Nude rodents bearing human U87-MG glioblastoma tumor xenografts in the flank (34 tumors in mice) or in the brain (5 tumors in rats) were analyzed. Kinetics of ⁶⁸Ga-NODAGA-RGD and of ¹⁸F-FDG were compared with PET imaging in the

SUBMITTER: Isal S 

PROVIDER: S-EPMC6003898 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature