Nano-particle mediated inhibition of Parkinson's disease using computational biology approach.

ABSTRACT: Parkinson's disease (PD) arises as neurodegenerative disorder and characterized by progressive deterioration of motor functions due to forfeiture of dopamine-releasing neurons. During PD, neurons at stake loss their functionality that results into cognition impairment and forgetfulness, commonly called as dementia. Recently, nanoparticles (NPs) have been reported for easy drug delivery through blood-brain barrier (BBB) into the central nervous system (CNS) against the conventional drug delivery systems. However, present study attempted to elucidate the α-synuclein activity, a major factor casing PD, in presence of its inhibitor cerium oxide (CeO₂) nanoparticle via computational biology approach. A computational analysis was also conducted for the α-synuclein activity with biocom

SUBMITTER: Kaushik AC 

PROVIDER: S-EPMC6003935 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature