Increased chronic kidney disease development and progression in diabetic patients after appendectomy: a population-based cohort study.

ABSTRACT:

Background

The vermiform appendix serves as a "safe house" for maintaining normal gut bacteria and appendectomy may impair the intestinal microbiota. Appendectomy is expected to profoundly alter the immune system and modulate the pathogenic inflammatory immune responses of the gut. Recent studies have shown that a dysbiotic gut increases the risk of cardiovascular disease and chronic kidney disease (CKD). Therefore, we hypothesized that appendectomy would increase the risk of CKD.

Methods

This nationwide, population-based, propensity-score-matched cohort study included 10,383 patients who underwent appendectomy and 41,532 propensity-score-matched controls. Data were collected by the National Health Insurance Research Database of Taiwan from 2000 to 2013. We examined the asso

SUBMITTER: Chang CH 

PROVIDER: S-EPMC6004103 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature