Changes in Protein O-GlcNAcylation During Mouse Epididymal Sperm Maturation.

ABSTRACT: After leaving the testis, sperm undergo two sequential maturational processes before acquiring fertilizing capacity: sperm maturation in the male epididymis, and sperm capacitation in the female reproductive tract. During their transit through the epididymis, sperm experience several maturational changes; the acquisition of motility is one of them. The molecular basis of the regulation of this process is still not fully understood. Sperm are both transcriptionally and translationally silent, therefore post-translational modifications are essential to regulate their function. The post-translational modification by the addition of O-linked β-N-acetylglucosamine (O-GlcNAc) can act as a counterpart of phosphorylation in different cellular processes. Therefore, our work was aimed to characteriz

SUBMITTER: Tourzani DA 

PROVIDER: S-EPMC6004373 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature