First-in-Human Human Epidermal Growth Factor Receptor 2-Targeted Imaging Using ⁸⁹Zr-Pertuzumab PET/CT: Dosimetry and Clinical Application in Patients with Breast Cancer.

ABSTRACT: In what we believe to be a first-in-human study, we evaluated the safety and dosimetry of ⁸⁹Zr-pertuzumab PET/CT for human epidermal growth factor receptor 2 (HER2)-targeted imaging in patients with HER2-positive breast cancer. Methods: Patients with HER2-positive breast cancer and evidence of distant metastases were enrolled in an institutional review board-approved prospective clinical trial. Pertuzumab was conjugated with deferoxamine and radiolabeled with ⁸⁹Zr. Patients underwent PET/CT with 74 MBq of ⁸⁹Zr-pertuzumab in a total antibody mass of 20-50 mg of pertuzumab. PET/CT, whole-body probe counts, and blood drawing were performed over 8 d to assess pharmacokinetics, biodistribution, and dosimetry. PET/CT images were evaluated for the ability t

SUBMITTER: Ulaner GA 

PROVIDER: S-EPMC6004559 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature