PET Using a GRPR Antagonist ⁶⁸Ga-RM26 in Healthy Volunteers and Prostate Cancer Patients.

ABSTRACT: This study was designed to analyze the safety, biodistribution, and radiation dosimetry of a gastrin-releasing peptide receptor (GRPR) antagonist PET tracer, ⁶⁸Ga-RM26; to assess its clinical diagnostic value in prostate cancer patients; and to perform a direct comparison between GRPR antagonist ⁶⁸Ga-RM26 and agonist ⁶⁸Ga-BBN. Methods: Five healthy volunteers were enrolled to validate the safety of ⁶⁸Ga-RM26 and calculate dosimetry. A total of 28 patients with prostate cancer (17 newly diagnosed and 11 posttherapy) were recruited and provided written informed consent. All the cancer patients underwent PET/CT at 15-30 min after intravenous injection of 1.85 MBq (0.05 mCi) per kilogram of body weight of ⁶⁸Ga-RM26. Among them, 22 p

SUBMITTER: Zhang J 

PROVIDER: S-EPMC6004560 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature