Ontology highlight
ABSTRACT:
SUBMITTER: Wijeratne A
PROVIDER: S-EPMC6004567 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
ACS medicinal chemistry letters 20180521 6
The KRASG12C protein product is an attractive, yet challenging, target for small molecule inhibition. One option for therapeutic intervention is to design small molecule ligands capable of binding to and inactivating KRASG12C via formation of a covalent bond to the sulfhydryl group of cysteine 12. In order to better understand the cellular off-target interactions of <b>Compound 1</b>, a covalent KRASG12C inhibitor, we have completed a series of complementary chemical proteomics experiments in H3 ...[more]