Evaluation of physicochemical properties as supporting information on quality control of raw materials and veterinary pharmaceutical formulations.

ABSTRACT: This study aimed to show that the physicochemical proprieties obtained by Fourier transform infrared spectroscopy (FTIR), thermogravimetry (TG), and scanning electronic microscopy (SEM) can be useful tools for evaluating the quality of active pharmaceutical ingredients (APIs) and pharmaceutical products. In addition, a simple, sensitive, and efficient method employing HPLC-DAD was developed for simultaneous determination of lidocaine (LID), ciprofloxacin (CFX) and enrofloxacin (EFX) in raw materials and in veterinary pharmaceutical formulations. Compounds were separated using a Gemini C₁₈ (250 mm × 4.6 mm, 5 µm) Phenomenex^® column, at a temperature of 25 °C, with a mobile phase containing 10 mM of phosphoric acid (pH 3.29): acetonitrile (85.7:14.3, v/v) and a flow rat

SUBMITTER: Anacleto SDS 

PROVIDER: S-EPMC6004627 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature