Stepwise participation of HGF/MET signaling in the development of migratory muscle precursors during vertebrate evolution.

ABSTRACT:

Background

The skeletal musculature of gnathostomes, which is derived from embryonic somites, consists of epaxial and hypaxial portions. Some hypaxial muscles, such as tongue and limb muscles, undergo de-epithelialization and migration during development. Delamination and migration of these myoblasts, or migratory muscle precursors (MMPs), is generally thought to be regulated by hepatocyte growth factor (HGF) and receptor tyrosine kinase (MET) signaling. However, the prevalence of this mechanism and the expression patterns of the genes involved in MMP development across different vertebrate species remain elusive.

Results

We performed a comparative analysis of Hgf and Met gene expression in several vertebrates, including mouse, chicken, dogfish (Scyliorhinus

SUBMITTER: Adachi N 

PROVIDER: S-EPMC6004694 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature