Association between Q192R polymorphism in the PON1 gene and statin responses in cardiac patients.

ABSTRACT:

Introduction

Paraoxonases are a group of different forms enzymes that consist of three non-similar isoforms, PON1, PON2 and PON3, which are located near to each other on the long arm of chromosome7. This study aims to investigate the association of a Q192R polymorphism of PON1 gene and statin response in patients with ischemic heart disease with dyslipidemia.

Methods

The studied population included three hundred patients with coronary artery disease with dyslipidemia who were prescribed statins. Total lipid profile was measured in these patients both before and after approximately 6 months of treatment. Q192R polymorphism of PON1 gene was assessed by real-time PCR.

Results

There were no significant differences in baseline lipid levels according to differ

SUBMITTER: Abd Elgwad ER 

PROVIDER: S-EPMC6004736 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature