Dietary NaCl affects bleomycin-induced lung fibrosis in mice.

ABSTRACT:

Purpose

High levels of NaCl in the diet are associated with both cardiac and renal fibrosis, but whether salt intake affects pulmonary fibrosis has not been examined.

Aim of the study

To test the hypothesis that salt intake might affect pulmonary fibrosis.

Materials and methods

Mice were fed low, normal, or high salt diets for 2 weeks, and then treated with oropharyngeal bleomycin to induce pulmonary fibrosis, or oropharyngeal saline as a control.

Results

As determined by collagen staining of lung sections, and protein levels and cell numbers in the bronchoalveolar lavage (BAL) fluid at 21 days after bleomycin, the high salt diet did not exacerbate bleomycin-induced fibrosis, while the low salt diet attenuated fibrosis. For the bleomycin-treated mice, staining

SUBMITTER: Chen W 

PROVIDER: S-EPMC6004787 | biostudies-literature | 2017 Nov - Dec

REPOSITORIES: biostudies-literature