Personalizing Survival Predictions in Advanced Colorectal Cancer: The ARCAD Nomogram Project.

ABSTRACT:

Background

Estimating prognosis on the basis of clinicopathologic factors can inform clinical practice and improve risk stratification for clinical trials. We constructed prognostic nomograms for one-year overall survival and six-month progression-free survival in metastatic colorectal carcinoma by using the ARCAD database.

Methods

Data from 22 674 patients in 26 randomized phase III clinical trials since 1997 were used to construct and validate Cox models, stratified by treatment arm within each study. Candidate variables included baseline age, sex, body mass index, performance status, colon vs rectal cancer, prior chemotherapy, number and location of metastatic sites, tumor mutation status (BRAF, KRAS), bilirubin, albumin, white blood cell count, hemoglobin, platelets, abs

SUBMITTER: Sjoquist KM 

PROVIDER: S-EPMC6005015 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature