Impact of intensification with raltegravir on HIV-1-infected individuals receiving monotherapy with boosted PIs.

ABSTRACT:

Background

Monotherapy with ritonavir-boosted PIs (PI/r) has been used to simplify treatment of HIV-1-infected patients. In previous studies raltegravir intensification evidenced ongoing viral replication and reduced T cell activation, preferentially in subjects receiving PI-based triple ART. However, data about low-level viral replication and its consequences in patients receiving PI/r monotherapy are scarce.

Methods

We evaluated the impact of 24 weeks of intensification with raltegravir on markers of viral persistence, cellular immune activation and inflammation biomarkers in 33 patients receiving maintenance PI/r monotherapy with darunavir or lopinavir boosted with ritonavir. ClinicalTrials.gov identifier: NCT01480713.

Results

The addition of raltegravir to PI/r mo

SUBMITTER: Puertas MC 

PROVIDER: S-EPMC6005067 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature