1,25 Dihydroxyvitamin D3 uptake is localized at caveolae and requires caveolar function.

ABSTRACT: Vitamin D3 is an essential vitamin that has been extensively studied due to its potential role as therapeutic for many diseases, including breast cancer. Previous research has indicated that calcitriol, the active form of Vitamin D3 has a negative effect on the metastatic ability of Inflammatory Breast Cancer (IBC) cells however the mechanism is not fully understood. The effect of calcitriol on IBC cells starting from cellular uptake must be investigated in order to understand these therapeutic effects. Calcitriol bound Quantum Dots (CalQDs) are a novel nanoparticle conjugated probe that can be used to directly examine the distribution, uptake, and signaling of calcitriol in live cells. Therefore we used these conjugated probes to directly investigate the uptake of calcitriol into live IBC

SUBMITTER: Schaefer RJ 

PROVIDER: S-EPMC6005177 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature