Proteomic analysis to identify candidate biomarkers associated with type 1 diabetes.

ABSTRACT:

Purpose

Type 1 diabetes mellitus (DM1) is one of the most common chronic diseases observed during childhood. The incidence of DM1 is increasing worldwide, and there is currently no way to prevent or delay the onset or to cure the disease. Most diseases, including diabetes, stem from abnormalities in the functioning of proteins, and some studies have reported the expression of protein variation to be involved in the development of DM1. Thus, the aim of this study was to investigate the differential expression of serum proteins in patients with DM1.

Materials and methods

Serum of patients with DM1 (n=30) and healthy controls (n=30) was collected. A proteomic approach was used with depletion of albumin and immunoglobulin G chromatography on serum samples followed by data-indepe

SUBMITTER: do Nascimento de Oliveira V 

PROVIDER: S-EPMC6005324 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature