Photoactivation of imatinib-antibody conjugate using low-energy visible light from Ru(ii)-polypyridyl cages.

ABSTRACT: Ru(ii)-polypyridyl cages with sterically bulky bidentate ligands provide efficient photochemical release of the anticancer drug imatinib using low energy visible light, imparting spatiotemporal control over drug bioavailability. The light-activated drug release is maintained when the Ru(ii) cage is covalently coupled to an antibody, which is expected to localize selectively on the tumor.

SUBMITTER: Rohrabaugh TN 

PROVIDER: S-EPMC6005383 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature