Spatially dependent alkyl quinolone signaling responses to antibiotics in Pseudomonas aeruginosa swarms.

ABSTRACT: There is a general lack of understanding about how communities of bacteria respond to exogenous toxins such as antibiotics. Most of our understanding of community-level stress responses comes from the study of stationary biofilm communities. Although several community behaviors and production of specific biomolecules affecting biofilm development and associated behavior have been described for Pseudomonas aeruginosa and other bacteria, we have little appreciation for the production and dispersal of secreted metabolites within the 2D and 3D spaces they occupy as they colonize, spread, and grow on surfaces. Here we specifically studied the phenotypic responses and spatial variability of alkyl quinolones, including the Pseudomonas quinolone signal (PQS) and members of the alkyl

SUBMITTER: Morales-Soto N 

PROVIDER: S-EPMC6005435 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature