Long-Term Outcomes after Protocolized Sedation versus Usual Care in Ventilated Pediatric Patients.

ABSTRACT:

Rationale

Whether a nurse-implemented goal-directed sedation protocol resulting in more awake yet calm intubated children affects postdischarge functional status, health-related quality of life, or risk for post-traumatic stress disorder is unknown.

Objectives

To compare postdischarge outcomes in children with acute respiratory failure cluster-randomized to a sedation protocol or usual care.

Methods

A stratified random sample of 1,360 patients from 31 centers in the RESTORE (Randomized Evaluation of Sedation Titration for Respiratory Failure) trial was assessed by mail, electronically, and/or telephone 6 months after ICU discharge. In treatment group comparisons, we controlled for age, baseline functional status, and severity of illness.

Measurements and main resul

SUBMITTER: Watson RS 

PROVIDER: S-EPMC6005554 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature