The transmission dynamics and diversity of human metapneumovirus in Peru.

ABSTRACT:

Background

The transmission dynamics of human metapneumovirus (HMPV) in tropical countries remain unclear. Further understanding of the genetic diversity of the virus could aid in HMPV vaccine design and improve our understanding of respiratory virus transmission dynamics in low- and middle-income countries.

Materials & methods

We examined the evolution of HMPV in Peru through phylogenetic analysis of 61 full genome HMPV sequences collected in three ecologically diverse regions of Peru (Lima, Piura, and Iquitos) during 2008-2012, comprising the largest data set of HMPV whole genomes sequenced from any tropical country to date.

Results

We revealed extensive genetic diversity generated by frequent viral introductions, with little evidence of local persistence. While con

SUBMITTER: Pollett S 

PROVIDER: S-EPMC6005599 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature