Pharmacological treatments for alleviating agitation in dementia: a systematic review and network meta-analysis.

ABSTRACT:

Aims

To determine the most efficacious and acceptable treatments of agitation in dementia.

Methods

MEDLINE, EMBASE, PsycINFO, CENTRAL and clinicaltrials.gov were searched up to 7 February 2017. Two independent reviewers selected randomized controlled trials (RCTs) of treatments to alleviate agitation in people with all-types dementia. Data were extracted using standardized forms and study quality was assessed using the revised Cochrane Risk of Bias Tool for RCTs. Data were pooled using meta-analysis. The primary outcome, efficacy, was 8-week response rates defined as a 50% reduction in baseline agitation score. The secondary outcome was treatment acceptability defined as treatment continuation for 8 weeks.

Results

Thirty-six RCTs comprising 5585 participants (30.9% ma

SUBMITTER: Kongpakwattana K 

PROVIDER: S-EPMC6005613 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature