Preventability of serious thromboembolic and bleeding events related to the use of oral anticoagulants: a prospective study.

ABSTRACT:

Aims

To determine the preventability of serious adverse drug reactions (ADRs) related to the use of direct oral anticoagulants (DOACs), and to explore contributing factors to preventable ADRs. Results were compared with vitamin K antagonists (VKAs).

Methods

We conducted a prospective observational study in the emergency departments of two teaching hospitals from July 2015 to January 2016. Patients admitted with a thrombotic or bleeding event while under DOAC or VKA were included. Four independent reviewers assessed causality, seriousness and preventability of ADRs using pilot-tested scales. For cases of serious and potentially preventable ADRs, we performed semi-structured interviews with general practitioners to identify contributing factors to ADRs. The primary outcome was

SUBMITTER: Sennesael AL 

PROVIDER: S-EPMC6005616 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature