Molecular genetic characteristics of influenza A virus clinically isolated during 2011-2016 influenza seasons in Korea.

ABSTRACT:

Background

The influenza virus is reportedly associated with 3-5 million cases of severe illness and 250 000-500 000 deaths annually worldwide.

Objectives

We investigated the variation of influenza A virus in Korea and examined the association with death.

Methods

A total of 13 620 cases were enrolled in the Hospital-based Influenza Morbidity & Mortality surveillance system in Korea during 2011-2016. Among these cases, a total of 4725 were diagnosed with influenza using RT-PCR (influenza A; n = 3696, influenza B; n = 928, co-infection; n = 101). We used 254 viral sequences from the 3696 influenza A cases for phylogenetic analysis using the BioEdit and MEGA 6.06 programs.

Results

We found that the sequences of A/H3N2 in the 2011-2012 season belong to subgroup 3C.

SUBMITTER: Lee HS 

PROVIDER: S-EPMC6005628 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature