Honokiol Decreases Lung Cancer Metastasis through Inhibition of the STAT3 Signaling Pathway.

ABSTRACT: Lung cancer is the leading cause of cancer death in the United States. Metastasis to lymph nodes and distal organs, especially brain, leads to severe complications and death. Preventing lung cancer development and metastases is an important strategy to reduce lung cancer mortality. Honokiol (HNK), a natural compound present in the extracts of magnolia bark, has a favorable bioavailability profile and recently has been shown to readily cross the blood-brain barrier. In the current study, we evaluated the antimetastatic effects of HNK in both the lymph node and brain mouse models of lung tumor metastasis. We tested the efficacy of HNK in preventing 18 H2030-BrM3 cell (brain-seeking human lung tumor cells) migration to lymph node or brain. In an orthotopic mouse model, HNK significantly decre

SUBMITTER: Pan J 

PROVIDER: S-EPMC6005650 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature