Single-Nucleotide Polymorphisms Associated With Age-Related Macular Degeneration and Lesion Phenotypes in the Comparison of Age-Related Macular Degeneration Treatments Trials.

ABSTRACT:

Importance

Single-nucleotide polymorphisms (SNPs) associated with the CFH, ARMS2, C3, LIPC, CFB, and C2 genes are associated with age-related macular degeneration (AMD); however, the association of these SNPs with angiographic features of neovascular AMD has been inconsistent in previous studies, and to date, no studies have addressed their association with features on optical coherence tomography.

Objective

To evaluate the influence of genotype of SNPs previously associated with AMD on the phenotype of neovascular lesions.

Design, setting, and participants

Participants for this cross-sectional study were recruited from the 1185 patients enrolled in the Comparison of Age-Related Macular Degeneration Treatments Trials (CATT), a randomized clinical trial. Eligibility cr

SUBMITTER: Maguire MG 

PROVIDER: S-EPMC6005698 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature