Periostin: A Matricellular Protein With Multiple Functions in Cancer Development and Progression.

ABSTRACT: Tumor microenvironment is considered nowadays as one of the main players in cancer development and progression. Tumor microenvironment is highly complex and consists of non-tumor cells (i.e., cancer-associated fibroblast, endothelial cells, or infiltrating leukocytes) and a large list of extracellular matrix proteins and soluble factors. The way that microenvironment components interact among them and with the tumor cells is very complex and only partially understood. However, it is now clear that these interactions govern and modulate many of the cancer hallmarks such as cell proliferation, the resistance to death, the differentiation state of tumor cells, their ability to migrate and metastasize, and the immune response against tumor cells. One of the microenvironment components that hav

SUBMITTER: Gonzalez-Gonzalez L 

PROVIDER: S-EPMC6005831 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature