Anticancer chemotherapy and radiotherapy trigger both non-cell-autonomous and cell-autonomous death.

ABSTRACT: Even though cell death modalities elicited by anticancer chemotherapy and radiotherapy have been extensively studied, the ability of anticancer treatments to induce non-cell-autonomous death has never been investigated. By means of multispectral imaging flow-cytometry-based technology, we analyzed the lethal fate of cancer cells that were treated with conventional anticancer agents and co-cultured with untreated cells, observing that anticancer agents can simultaneously trigger cell-autonomous and non-cell-autonomous death in treated and untreated cells. After ionizing radiation, oxaliplatin, or cisplatin treatment, fractions of treated cancer cell populations were eliminated through cell-autonomous death mechanisms, while other fractions of the treated cancer cells engulfed and killed nei

SUBMITTER: Martins I 

PROVIDER: S-EPMC6006149 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature