Genome-wide assessment of gene-by-smoking interactions in COPD.

ABSTRACT: Cigarette smoke exposure is a major risk factor in chronic obstructive pulmonary disease (COPD) and its interactions with genetic variants could affect lung function. However, few gene-smoking interactions have been reported. In this report, we evaluated the effects of gene-smoking interactions on lung function using Korea Associated Resource (KARE) data with the spirometric variables-forced expiratory volume in 1 s (FEV₁). We found that variations in FEV₁ were different among smoking status. Thus, we considered a linear mixed model for association analysis under heteroscedasticity according to smoking status. We found a previously identified locus near SOX9 on chromosome 17 to be the most significant based on a joint test of the main and interaction effects of smokin

SUBMITTER: Park B 

PROVIDER: S-EPMC6006158 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature