Signatures of historical selection on MHC reveal different selection patterns in the moor frog (Rana arvalis).

ABSTRACT: MHC genes are key components in disease resistance and an excellent system for studying selection acting on genetic variation in natural populations. Current patterns of variation in MHC genes are likely to be influenced by past and ongoing selection as well as demographic fluctuations in population size such as those imposed by post-glacial recolonization processes. Here, we investigated signatures of historical selection and demography on an MHC class II gene in 12 moor frog populations along a 1700-km latitudinal gradient. Sequences were obtained from 207 individuals and consecutively assigned into two different clusters (northern and southern clusters, respectively) in concordance with a previously described dual post-glacial colonization route. Selection analyses comparing the relativ

SUBMITTER: Cortazar-Chinarro M 

PROVIDER: S-EPMC6006221 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature