Regulatory T cells control endothelial chemokine production and migration of T cells into intestinal tumors of APC^min/+ mice.

ABSTRACT: Tumor-infiltrating lymphocytes are crucial for anti-tumor immunity. We have previously shown that regulatory T cells (Treg) are able to reduce T-cell transendothelial migration in vitro and accumulation of effector T cells in intestinal tumors in vivo. Treg depletion also resulted in increased levels of the chemokines CXCL9 and CXCL10 specifically in the tumors. In this study, we investigated the mechanisms for Treg mediated suppression of T-cell migration into intestinal tumors in the APC^min/+ mouse model. By breeding APC^min/+ mice with DEREG mice, which harbour a high affinity diphtheria toxin receptor under the control of the FOXP3 promoter, we were able to deplete Treg in tumor-bearing mice. Using adoptive transfer experiments, we could document a markedly increas

SUBMITTER: Akeus P 

PROVIDER: S-EPMC6006230 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature