Molecular signature of progenitor cells isolated from young and adult human hearts.

ABSTRACT: The loss of endogenous cardiac regenerative capacity within the first week of postnatal life has intensified clinical trials to induce cardiac regeneration in the adult mammalian heart using different progenitor cell types. We hypothesized that donor age-related phenotypic and functional characteristics of cardiac progenitor cells (CPC) account for mixed results of cell-based cardiac repair. We compared expression profiles and cell turnover rates of human heart-derived c-kit^pos progenitors (c-kit^pos CPC) and cardiosphere-derived cells (CDC) from young and adult donor origin and studied their in vitro angiogenic and cardiac differentiation potential, which can be relevant for cardiac repair. We report that 3-dimensional CDC expansion recapitulates a conducive environme

SUBMITTER: Walravens AS 

PROVIDER: S-EPMC6006291 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature