Liver X receptors regulate hepatic F4/80 ⁺ CD11b⁺ Kupffer cells/macrophages and innate immune responses in mice.

ABSTRACT: The liver X receptors (LXRs), LXRα and LXRβ, are nuclear receptors that regulate lipid homeostasis. LXRs also regulate inflammatory responses in cultured macrophages. However, the role of LXRs in hepatic immune cells remains poorly characterized. We investigated the role of LXRs in regulation of inflammatory responses of hepatic mononuclear cells (MNCs) in mice. Both LXRα and LXRβ were expressed in mouse hepatic MNCs and F4/80⁺ Kupffer cells/macrophages. LXRα/β-knockout (KO) mice had an increased number of hepatic MNCs and elevated expression of macrophage surface markers and inflammatory cytokines compared to wild-type (WT) mice. Among MNCs, F4/80⁺CD11b⁺ cells, not F4/80⁺CD11b^- or F4/80⁺CD68⁺ cells, were increase

SUBMITTER: Endo-Umeda K 

PROVIDER: S-EPMC6006359 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature