Controlled semantic cognition relies upon dynamic and flexible interactions between the executive 'semantic control' and hub-and-spoke 'semantic representation' systems.

ABSTRACT: Built upon a wealth of neuroimaging, neurostimulation, and neuropsychology data, a recent proposal set forth a framework termed controlled semantic cognition (CSC) to account for how the brain underpins the ability to flexibly use semantic knowledge (Lambon Ralph et al., 2017; Nature Reviews Neuroscience). In CSC, the 'semantic control' system, underpinned predominantly by the prefrontal cortex, dynamically monitors and modulates the 'semantic representation' system that consists of a 'hub' (anterior temporal lobe, ATL) and multiple 'spokes' (modality-specific areas). CSC predicts that unfamiliar and exacting semantic tasks should intensify communication between the 'control' and 'representation' systems, relative to familiar and less taxing tasks. In the present study, we used functional

SUBMITTER: Chiou R 

PROVIDER: S-EPMC6006425 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature