Interactions between COL5A1 Gene and Risk of the Anterior Cruciate Ligament Rupture.

ABSTRACT: Collagen alpha-1(V) chain, encoded by the COL5A1 gene, plays a crucial role in abundant fibrillar collagens supporting many tissues in the body containing type I collagen and appears to regulate the association between heterotypic fibers composed of both type I and type V collagen occurring among others in muscles, tendons and ligaments. Taking this fact into consideration we decided to examine the association between COL5A1 rs12722 and rs13946 polymorphisms, individually and as inferred haplotypes, with anterior cruciate ligament rupture risk (ACLR) in professional soccer players. A total of 134 male professional soccer players with surgically diagnosed primary anterior cruciate ligament ruptures and 211 apparently healthy male professional soccer players, who were without any self-report

SUBMITTER: Lulinska-Kuklik E 

PROVIDER: S-EPMC6006531 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature