Identification and characterization of DNA endonucleases in Plasmodium falciparum 3D7 clone.

ABSTRACT:

Background

Plasmodium falciparum is the most virulent parasite of the five Plasmodium species that cause human malaria, and biological analysis of the parasite is critical for the development of novel strategies for disease control. DNA endonucleases are important for maintaining the biological activity, gene stability of the parasite and interaction with host immune systems. In this study, ten sequences of DNA endonucleases were found in the genome of P. falciparum 3D7 clone, seven of them were predicted to contain an endonuclease/exonuclease/phosphatase (IPR005135) domain which plays an important role in DNA catalytic activity. The seven DNA endonucleases of P. falciparum were systematically investigated.

Methods

Plasmodium falciparum 3D7 clone was cultured in human O

SUBMITTER: Jiang N 

PROVIDER: S-EPMC6006590 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature