Motifome comparison between modern human, Neanderthal and Denisovan.

ABSTRACT:

Background

The availability of the genomes of two archaic humans, Neanderthal and Denisovan, and that of modern humans provides researchers an opportunity to investigate genetic differences between these three subspecies on a genome-wide scale. Here we describe an algorithm that predicts statistically significant motifs based on the difference between a given motif's actual and expected distributions. The algorithm was previously applied to plants but was modified for this work.

Results

The result of applying the algorithm to the human, Neanderthal, and Denisovan genomes is a catalog of potential regulatory motifs in these three human subspecies. We examined the distributions of these motifs in genetic elements including human retroviruses, human accelerated regions, and hum

SUBMITTER: Cserhati MF 

PROVIDER: S-EPMC6006668 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature