Exploring the key genes and pathways of side population cells in human osteosarcoma using gene expression array analysis.

ABSTRACT:

Background

Human osteosarcoma (OS) is one of the most common primary bone sarcoma, because of early metastasis and few treatment strategies. It has been reported that the tumorigenicity and self-renewal capacity of side population (SP) cells play roles in human OS via regulating of target genes. This study aims to complement the differentially expressed genes (DEGs) that regulated between the SP cells and the non-SP cells from primary human OS and identify their functions and molecular pathways associated with OS.

Methods

The gene expression profile GSE63390 was downloaded, and bioinformatics analysis was made.

Results

One hundred forty-one DEGs totally were identified. Among them, 72 DEGs (51.06%) were overexpressed, and the remaining 69 DEGs (48.94%) were underexpre

SUBMITTER: Ren YM 

PROVIDER: S-EPMC6006685 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature