Extracellular release of virulence factor major surface protease via exosomes in Leishmania infantum promastigotes.

ABSTRACT:

Background

The Leishmania spp. protozoa are introduced into humans through a sand fly blood meal, depositing the infectious metacyclic promastigote form of the parasite into human skin. Parasites enter a variety of host cells, although a majority are found in macrophages where they replicate intracellularly during chronic leishmaniasis. Symptomatic leishmaniasis causes considerable human morbidity in endemic regions. The Leishmania spp. evade host microbicidal mechanisms partially through virulence-associated proteins such as the major surface protease (MSP or GP63), to inactivate immune factors in the host environment. MSP is a metalloprotease encoded by a tandem array of genes belonging to three msp gene classes, whose mRNAs are differentially expressed in different life stages o

SUBMITTER: Marshall S 

PROVIDER: S-EPMC6006689 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature