High CD44 expression mediates p62-associated NFE2L2/NRF2 activation in breast cancer stem cell-like cells: Implications for cancer stem cell resistance.

ABSTRACT: Cluster of differentiation 44 (CD44) is the most common cancer stem cell (CSC) marker and high CD44 expression has been associated with anticancer drug resistance, tumor recurrence, and metastasis. In this study, we aimed to investigate the molecular mechanism by which CD44 and nuclear factor erythroid 2-like 2 (NFE2L2; NRF2), a key regulator of antioxidant genes, are linked to CSC resistance using CD44^high breast CSC-like cells. NRF2 expression was higher in CD44^high cell populations isolated from doxorubicin-resistant MCF7 (ADR), as well as MCF7, MDA-MB231, and A549 cells, than in corresponding CD44^low cells. High NRF2 expression in the CD44^highCD24^low CSC population (ADR44P) established from ADR cells depended on standard isoform of

SUBMITTER: Ryoo IG 

PROVIDER: S-EPMC6006726 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature