Cooperation of PD-1 and LAG-3 in the exhaustion of CD4⁺ and CD8⁺ T cells during bovine leukemia virus infection.

ABSTRACT: Bovine leukemia virus (BLV) is a retrovirus that infects B cells in cattle and causes bovine leukosis after a long latent period. Progressive exhaustion of T cell functions is considered to facilitate disease progression of BLV infection. Programmed death-1 (PD-1) and lymphocyte activation gene-3 (LAG-3) are immunoinhibitory receptors that contribute to T-cell exhaustion caused by BLV infection in cattle. However, it is unclear whether the cooperation of PD-1 and LAG-3 accelerates disease progression of BLV infection. In this study, multi-color flow cytometric analyses of PD-1- and LAG-3-expressing T cells were performed in BLV-infected cattle at different stages of the disease. The frequencies of PD-1⁺LAG-3⁺ heavily exhausted T cells among CD4⁺ and CD8

SUBMITTER: Okagawa T 

PROVIDER: S-EPMC6006750 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature