Phylogenetic and genomic analyses of the ribosomal oxygenases Riox1 (No66) and Riox2 (Mina53) provide new insights into their evolution.

ABSTRACT:

Background

Translation of specific mRNAs can be highly regulated in different cells, tissues or under pathological conditions. Ribosome heterogeneity can originate from variable expression or post-translational modifications of ribosomal proteins. The ribosomal oxygenases RIOX1 (NO66) and RIOX2 (MINA53) modify ribosomal proteins by histidine hydroxylation. A similar mechanism is present in prokaryotes. Thus, ribosome hydroxylation may be a well-conserved regulatory mechanism with implications in disease and development. However, little is known about the evolutionary history of Riox1 and Riox2 genes and their encoded proteins across eukaryotic taxa.

Results

In this study, we have analysed Riox1 and Riox2 orthologous genes from 49 metazoen species and have constructed phyloge

SUBMITTER: Brauer KE 

PROVIDER: S-EPMC6006756 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature