Effects of local anesthetics on breast cancer cell viability and migration.

ABSTRACT:

Background

Breast cancer accounts for nearly a quarter of all cancers in women worldwide, and more than 90% of women diagnosed with breast cancer undergo mastectomy or breast-conserving surgery. Retrospective clinical studies have suggested that use of regional anesthesia leads to improved patient outcomes. Laboratory studies have reported that breast cancer cells are inhibited by some local anesthetics at millimolar concentration. Here, we present a comprehensive analysis of the effects of six common local anesthetics on two human breast cancer cell lines. We used concentrations ranging from those corresponding to plasma levels during regional block by local anesthetic (plasma concentration) to those corresponding to direct infiltration of local anesthetic.

Methods

Human br

SUBMITTER: Li R 

PROVIDER: S-EPMC6006780 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature