Sex and strain dependent differences in mucosal immunology and microbiota composition in mice.

ABSTRACT:

Background

A dysbiosis in the intestinal microbiome plays a role in the pathogenesis of several immunological diseases. These diseases often show a sex bias, suggesting sex differences in immune responses and in the intestinal microbiome. We hypothesized that sex differences in immune responses are associated with sex differences in microbiota composition.

Methods

Fecal microbiota composition (MITchip), mRNA expression in intestinal tissue (microarray), and immune cell populations in mesenteric lymph nodes (MLNs) were studied in male and female mice of two mouse strains (C57B1/6OlaHsd and Balb/cOlaHsd). Transcriptomics and microbiota data were combined to identify bacterial species which may potentially be related to sex-specific differences in intestinal immune related gene

SUBMITTER: Elderman M 

PROVIDER: S-EPMC6006852 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature