Evolutionary analysis of rabies virus isolates from Guangxi Province of southern China.

ABSTRACT:

Background

Rabies is a severe epidemic in Guangxi province, China, with hundreds of deaths occurring each year. In the past six decades, rabies has emerged three times in Guangxi, and the province has reported the largest number of rabies cases in China. The domestic dog is the principal vector for rabies, and 95% of human cases are associated with transmission from dogs.

Results

To understand the genetic relationship between street rabies virus (RABV) from Guangxi, genetic diversity analysis was performed using RABV isolates collected between 1999 and 2012. The N gene of 42 RABV isolates, and the P and M genes, as well as fragments of the 3' terminus (L^1-680) and the polymerase activity module of the L gene (L^pam) of 36 RABV isolates were sequenced. In

SUBMITTER: Wei XK 

PROVIDER: S-EPMC6006964 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature