Cerebral Oximetry for Detecting High-mortality Risk Patients with Cryptococcal Meningitis.

ABSTRACT:

Background

Cryptococcus is the commonest cause of adult meningitis in Africa, with 50%-70% experiencing increased intracranial pressure. Cerebral oximetry is a noninvasive near-infrared spectroscopy technology to monitor percent regional cerebral tissue oxygenation (rSO₂). We assessed if cerebral oximetry predicts meningitis mortality.

Methods

We performed cerebral oximetry within 14 days of cryptococcal meningitis diagnosis on 121 Ugandans from April 2016 to September 2017. We evaluated baseline rSO₂ association with mortality by multivariable logistic regression and correlation with other clinical factors. We compared groups formed by initial rSO₂ <30% vs ≥30% for longitudinal change with mixed effects models. We measured change in %

SUBMITTER: Diehl JW 

PROVIDER: S-EPMC6007269 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature